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Activated by l-α-lysophosphatidylinositol (LPI), and to a lesser extent possibly by THC, CBD,O-1602, PEA, 2-AG, Anandamide, Virodhamine Cannabinoid Receptor Ligands (full – undated) http://www.tocris.com/pdfs/cannabinoid_receptor_review/page_001.html

Evolutionary Origins of the Endocannabinoid System. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16434153

GPR55: a new member of the cannabinoid receptor clan? (full – 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2095104/?tool=pubmed

The orphan receptor GPR55 is a novel cannabinoid receptor. (full – 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2095107/?tool=pubmed

GPR55 and the vascular receptors for cannabinoids. (full – 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190021/?tool=pubmed

The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects. (full – 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190033/?tool=pubmed

GPR55 and the vascular receptors for cannabinoids. (full – 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190021/?tool=pubmed

GPR55 is a novel cannabinoid receptor (full – 2007) http://www.biomedcentral.com/1471-2210/7/S2/A3

Novel cannabinoid receptors (full – 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190013/?tool=pmcentrez

CB1 receptors mediate the analgesic effects of cannabinoids on colorectal distension induced visceral pain in rodents. (full – 2007) http://www.jneurosci.org/content/29/5/1554.long

GPR55: signaling pathways and functions (abst – 2007) http://www.biomedcentral.com/1471-2210/9/S2/A3

GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268199/?tool=pubmed

Interactions of the G protein-coupled receptor-associated sorting proteins (GASP) 1 and 2 with the novel cannabinoid receptor GPR55 (abst – 2008) http://www.biomedcentral.com/1471-2210/8/S1/A16

The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737440/?tool=pubmed

Receptors for acylethanolamides-GPR55 and GPR119. (full – 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751869/?tool=pubmed

Endocannabinoids and the gastrointestinal tract: what are the key questions? (full - 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190011/

Cannabinoid receptor ligands as potential anticancer agents--high hopes for new therapies? (full – 2009) https://d3gqux9sl0z33u.cloudfront.net/AA/AE/gertschgroup/downloads/15931/Oesch___Gertsch_2009.pdf

Endocannabinoid-mediated control of synaptic transmission. (full – 2009) http://physrev.physiology.org/content/89/1/309.long

The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation. (full – 2009) http://www.fasebj.org/content/23/1/183.long

Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands. (full – 2009) http://www.jbc.org/content/284/43/29817.full?sid=ec54c280-2526-4d1b-ab9f-73a1ca683a5e

Receptors for acylethanolamides-GPR55 and GPR119. (full – 2009) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751869/?tool=pubmed

Is GPR55 an anandamide receptor? (abst – 2009) http://www.ncbi.nlm.nih.gov/pubmed/19647110

The enigmatic pharmacology of GPR55. (abst – 2009) http://www.ncbi.nlm.nih.gov/pubmed/19233486.

Mode of action of cannabinoids on nociceptive nerve endings. (abst – 2009) http://www.frontiersin.org/publications/19306092

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2 (full – 2010) http://pharmrev.aspetjournals.org/content/62/4/588.full.pdf+html

GPR55 ligands promote receptor coupling to multiple signalling pathways. (full – 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931561/?tool=pubmed

A role for L-alpha-lysophosphatidylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells. (full – 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931574/

Pharmacological characterization of GPR55, a putative cannabinoid receptor. (full – 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874616/pdf/nihms189321.pdf

Endocannabinoid-like N-arachidonoyl serine is a novel pro-angiogenic mediator. (full– 2010) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936832/

GPR55: Current Knowledge and Future Perspectives of a Purported "Type-3" Cannabinoid Receptor. (abst - 2010) http://www.ncbi.nlm.nih.gov/pubmed/20166924

Cannabinoids and the gut: new developments and emerging concepts (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20117132

Cannabinoids and Bone: Friend or Foe? (abst – 2010) http://www.ncbi.nlm.nih.gov/pubmed/20532878

Pharmacology of GPR55 in yeast and identification of GSK494581A as a mixed-activity glycine transporter subtype 1 inhibitor and GPR55 agonist. (full – 2011) http://jpet.aspetjournals.org/content/337/1/236.long

The Type 2 Cannabinoid Receptor Regulates Bone Mass and Ovariectomy-Induced Bone Loss by Affecting Osteoblast Differentiation and Bone Formation (full – 2011) http://press.endocrine.org/doi/full/10.1210/en.2010-0930

The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116968/

Lipid bilayer molecular dynamics study of lipid-derived agonists of the putative cannabinoid receptor, GPR55. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086297/?tool=pubmed

Screening for Selective Ligands for GPR55. (full – 2011) http://www.ncbi.nlm.nih.gov/books/NBK66153/

GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132458/pdf/cr201160a.pdf

New blood brothers: the GPR55 and CB2 partnership (full – 2011) http://www.nature.com/cr/journal/vaop/ncurrent/full/cr201177a.html

A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans. (full – 2011) http://joe.endocrinology-journals.org/content/211/2/177.long

The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116968/

What is the natural ligand of GPR55? (full – 2011) http://jb.oxfordjournals.org/content/149/5/495.full

A novel CB receptor GPR55 and its ligands are involved in regulation of gut movement in rodents. (full – 2011) http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2982.2011.01742.x/full

L-α-lysophosphatidylinositol meets GPR55: a deadly relationship. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21367464

Pharmacology, Signaling and Physiological Relevance of the G Protein-coupled Receptor 55. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21907912

The GPCR - associated sorting protein 1 regulates ligand-induced downregulation of GPR55. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21718301

Anandamide exerts its antiproliferative actions on cholangiocarcinoma by activation of the GPR55 receptor. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21464819

The novel cannabinoid receptor GPR55, inhibits cholangiocarcinoma growth (abst – 2011) http://www.fasebj.org/cgi/content/meeting_abstract/25/1_MeetingAbstracts/1117.3?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=80&sortspec=date&resourcetype=HWCIT

Modulation of the novel cannabinoid receptor - GPR55 - during rat fetoplacental development (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21497900

The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21683763

Pharmacology, signaling and physiological relevance of the G protein-coupled receptor 55. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21907912

Functional polymorphism in the GPR55 gene is associated with anorexia nervosa. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/20506567

The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/20838378

Off-Target Cannabinoid Effects Mediated by GPR55. (full – 2012) http://content.karger.com/produktedb/produkte.asp?DOI=000336872&typ=pdf

Role of cannabinoids in the regulation of bone remodeling (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499879/

The L-α-lysophosphatidylinositol/GPR55 system and its potential role in human obesity. (full – 2012) http://diabetes.diabetesjournals.org/content/61/2/281.long

Effects of Palmitoylethanolamide on Aqueous Humor Outflow. (full – 2012) http://www.iovs.org/content/53/8/4416.long

The Endocannabinoids Anandamide and Virodhamine Modulate the Activity of the Candidate Cannabinoid Receptor GPR55. (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669693/

Cannabinoid 2 (CB2) Receptor Involvement in the Down-regulation but not Upregulation of Serum IgE Levels in Immunized Mice. (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419805/

The cannabinoid receptor CB1 modulates the signaling properties of the lysophosphatidylinositol receptor GPR55. (full – 2012) http://www.jbc.org/content/early/2012/11/16/jbc.M112.364109.long

Cannabinoid Receptors CB1 and CB2 Form Functional Heteromers in Brain. (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375509/

G-Protein-Coupled Receptors in Intestinal Chemosensation (full – 2012) http://www.sciencedirect.com/science/article/pii/S1550413112000198

Evidence for the Putative Cannabinoid Receptor (GPR55)-Mediated Inhibitory Effects on Intestinal Contractility in Mice. (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548934/

The atypical cannabinoid O-1602 increases hind paw sensitisation in the chronic constriction injury model of neuropathic pain. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22227298

The interaction between intrathecal administration of low doses of palmitoylethanolamide and AM251 in formalin-induced pain related behavior and spinal cord IL1-β expression in rats. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22201038

GPR55 and GPR35 and their relationship to cannabinoid and lysophospholipid receptors. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22820167

A homology modeling study toward the understanding of three-dimensional structure and putative pharmacological profile of the G-protein coupled receptor GPR55. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/23220281

The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors (full – 2013) http://onlinelibrary.wiley.com/doi/10.1111/bph.12445/full

GPR55, a G-Protein Coupled Receptor for Lysophosphatidylinositol, Plays a Role in Motor Coordination. (full – 2013) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0060314

Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses. (full – 2013) http://www.pnas.org/content/early/2013/03/06/1211204110.full.pdf+html

Role of endogenous cannabinoid system in the gut. (full – 2013) http://www.actaps.com.cn/qikan/manage/wenzhang/2013-4-12.pdf

A potential role for GPR55 in gastrointestinal functions. (full – 2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660623/

The Natural Product Magnolol as a Lead Structure for the Development of Potent Cannabinoid Receptor Agonists (full – 2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813752/

A role for O-1602 and G protein-coupled receptor GPR55 in the control of colonic motility in mice. (full – 2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677091/

Rod Photoreceptors Express GPR55 in the Adult Vervet Monkey Retina. (full – 2013) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0081080

Genetic Background Can Result in a Marked or Minimal Effect of Gene Knockout (GPR55 and CB2 Receptor) in Experimental Autoimmune Encephalomyelitis Models of Multiple Sclerosis. (full – 2013) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0076907

Magnolia extract, magnolol and metabolites: activation of cannabinoid CB2 receptors and blockade of the related GPR55 (full – 2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027495/

A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function. (full – 2013) http://jpet.aspetjournals.org/content/346/1/54.long

The Endocannabinoid System and Sex Steroid Hormone-Dependent Cancers (full – 2013) http://www.hindawi.com/journals/ije/2013/259676/

A potential role for GPR55 in gastrointestinal functions. (full – 2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660623/

Orphan G protein receptor GPR55 as an emerging target in cancer therapy and management. (full – 2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706254/

GPR55 and its Interaction with Membrane Lipids: Comparison with Other Endocannabinoid-Binding Receptors (link to PDF – 2013) http://www.eurekaselect.com/105678/article

The actions and metabolism of lysophosphatidylinositol, an endogenous agonist for GPR55. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/23714700

Cannabinoid receptor modulation of the endothelial cell inflammatory response (abst – 2013) http://www.jimmunol.org/cgi/content/meeting_abstract/190/1_MeetingAbstracts/112.29?sid=c3422dd2-7ad0-42e4-a862-845dc670f7cf

Regulation of cell proliferation by GPR55/cannabinoid receptors using (R,R')-4’-methoxy-1-naphthylfenoterol in rat C6 glioma cell line (abst – 2013) http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=695437a2-7613-4bef-8697-2294df2da859&cKey=18ba6eb0-2c5f-4004-a56f-2d1f450e2ed1&mKey=9b2d28e7-24a0-466f-a3c9-07c21f6e9bc9

Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/22850623

The G protein-coupled receptor 55 ligand l-α-lysophosphatidylinositol exerts microgliadependent neuroprotection after excitotoxic lesion. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/24038453

(R,R’)-4’-methoxy-1-naphthylfenoterol Inhibits GPR55 signaling and the modulation of motility in human cancer cells (abst – 2013) http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=25370896-7d13-4f15-be76-f664d79b577d&cKey=87b7fec1-45cc-42b7-aca7-48c6b1d42773&mKey=9b2d28e7-24a0-466f-a3c9-07c21f6e9bc9

Evaluation of the insulin releasing and antihyperglycaemic activities of GPR55 lipid agonists using clonal beta-cells, isolated pancreatic islets and mice. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/23992544

Anticancer activity of anandamide in human cutaneous melanoma cells. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/24041928

Differential expression and functional role of cannabinoid genes in alcohol users. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/24060590

Identification of the GPR55 Antagonist Binding Site Using a Novel Set of High Potency GPR55 Selective Ligands. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/24274581

Increase of mesenchymal stem cell migration by Cannabidiol via activation of p42/44 MAPK. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/24304686

(R,R')-4'-Methoxy-1-naphthylfenoterol Targets GPR55-mediated Ligand Internalization and Impairs Cancer Cell Motility. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/24355564

Regulation of GPR55 in rat white adipose tissue and serum LPI by nutritional status, gestation, gender and pituitary factors. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/24378736

The endocannabinoid/endovanilloid N-arachidonoyl dopamine (NADA) and synthetic cannabinoid WIN55,212-2 abate the inflammatory activation of human endothelial cells. (full – 2014) http://www.jbc.org/content/early/2014/03/18/jbc.M113.536953.long

Vascular targets for cannabinoids: animal and human studies. (full – 2014) http://onlinelibrary.wiley.com/doi/10.1111/bph.12560/full

Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders (full – 2014) http://onlinelibrary.wiley.com/doi/10.1111/epi.12631/full

CB2 Receptor Activation Inhibits Melanoma Cell Transmigration through the Blood-Brain Barrier. (full – 2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057719/

Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24854329

Role of Endocannabinoid Activation of Peripheral CB1 Receptors in the Regulation of Autoimmune Disease. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24911431

CB1 and GPR55 receptors are co-expressed and form heteromers in rat and monkey striatum. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24967683

GPR55: From orphan to metabolic regulator? (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24972076

Heteromerization of GPR55 and cannabinoid CB2 receptors modulates signaling. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/25048571

Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling (abst – 2014) http://www.jbc.org/content/early/2014/07/02/jbc.M114.561761.abstract?sid=58027e04-8d1d-47c5-b6d3-49611e578de4

The endocannabinoid/endovanilloid N-arachidonoyl dopamine (NADA) and synthetic cannabinoid WIN55,212-2 abate the inflammatory activation of human endothelial cells. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24644287

UEA research reveals how cannabis compound could slow tumour growth (news – 2014) http://www.alphagalileo.org/ViewItem.aspx?ItemId=143664&CultureCode=en

How marijuana shrinks cancerous tumours (news – 2014) https://en-maktoob.news.yahoo.com/marijuana-shrinks-cancerous-tumours-122611456.html

October 1, 2014 at 8:18 AM Flag Quote & Reply

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